Ivan Maryshev is a postdoctoral fellow at LMU München working with Prof. Erwin Frey an supported by independent funding from Horizon Europe: Marie Skłodowska-Curie Actions. His research is focused on the active cytoskeleton, active droplets, and vesicles. Ivan graduated from MIPT (Moscow Institute of Physics and Technology) and earned his Ph.D. in Biophysics at the University of Edinburgh.
Tuesday April 18th
Mitotic spindle in terms of active matter
Microtubules and molecular motors can work cooperatively to construct a mitotic spindle – a complex structure that orchestrates many spatiotemporal processes during cell division.
The central part of the spindle contains nematically aligned microtubules organized by sliding motors, while closer to the spindle poles, filaments are focused by clustering motors and can form radial arrays.
I will try to shed light on the mitotic spindle self-assembly using the Boltzmann formalism and Landau theory. In Particular, we will discuss how to derive macroscopic hydrodynamic equations by coarse-graining the interactions between individual elements and how to construct a phenomenological continuum model of spindle formation.